Personality, addiction, dopamine: insights from Parkinson's disease.
Identifieur interne : 001D95 ( Main/Exploration ); précédent : 001D94; suivant : 001D96Personality, addiction, dopamine: insights from Parkinson's disease.
Auteurs : Alain Dagher [Canada] ; Trevor W. RobbinsSource :
- Neuron [ 1097-4199 ] ; 2009.
English descriptors
- KwdEn :
- Antiparkinson Agents, Behavior, Addictive (physiopathology), Behavior, Addictive (psychology), Dopamine (physiology), Gambling (psychology), Humans, Impulsive Behavior (physiopathology), Impulsive Behavior (psychology), Learning (physiology), Neostriatum (physiopathology), Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Personality (physiology), Positron-Emission Tomography, Substance-Related Disorders (psychology).
- MESH :
- chemical , physiology : Dopamine.
- chemical : Antiparkinson Agents.
- diagnostic imaging : Parkinson Disease.
- physiology : Learning, Personality.
- physiopathology : Behavior, Addictive, Impulsive Behavior, Neostriatum, Parkinson Disease.
- psychology : Behavior, Addictive, Gambling, Impulsive Behavior, Parkinson Disease, Substance-Related Disorders.
- Humans, Positron-Emission Tomography.
Abstract
In rare instances, patients with Parkinson's disease (PD) may become addicted to their own medication or develop behavioral addictions such as pathological gambling. This is surprising because PD patients typically have a very low incidence of drug abuse and display a personality type that is the polar opposite of the addictive personality. These rare addictive syndromes, which appear to result from excessive dopaminergic medication use, illustrate the link between dopamine, personality, and addiction. We describe the clinical phenomena and attempt to relate them to current models of learning and addiction. We conclude that persistently elevated dopaminergic stimulation promotes the development and maintenance of addictive behaviors.
DOI: 10.1016/j.neuron.2009.01.031
PubMed: 19249271
Affiliations:
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Le document en format XML
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Robbins</name></author></analytic><series><title level="j">Neuron</title><idno type="eISSN">1097-4199</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents</term><term>Behavior, Addictive (physiopathology)</term><term>Behavior, Addictive (psychology)</term><term>Dopamine (physiology)</term><term>Gambling (psychology)</term><term>Humans</term><term>Impulsive Behavior (physiopathology)</term><term>Impulsive Behavior (psychology)</term><term>Learning (physiology)</term><term>Neostriatum (physiopathology)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Personality (physiology)</term><term>Positron-Emission Tomography</term><term>Substance-Related Disorders (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Learning</term><term>Personality</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Behavior, Addictive</term><term>Impulsive Behavior</term><term>Neostriatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Behavior, Addictive</term><term>Gambling</term><term>Impulsive Behavior</term><term>Parkinson Disease</term><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Positron-Emission Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In rare instances, patients with Parkinson's disease (PD) may become addicted to their own medication or develop behavioral addictions such as pathological gambling. This is surprising because PD patients typically have a very low incidence of drug abuse and display a personality type that is the polar opposite of the addictive personality. These rare addictive syndromes, which appear to result from excessive dopaminergic medication use, illustrate the link between dopamine, personality, and addiction. We describe the clinical phenomena and attempt to relate them to current models of learning and addiction. We conclude that persistently elevated dopaminergic stimulation promotes the development and maintenance of addictive behaviors.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Robbins, Trevor W" sort="Robbins, Trevor W" uniqKey="Robbins T" first="Trevor W" last="Robbins">Trevor W. Robbins</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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